Rhnull phenotype is a rare blood group characterized by the lack of expression of all Rh antigens (D, C, c, E and e) on the red cells. The phenotype is further classified into the regulator and amorph type based on underlying genetic defect. The clinical significance of its recognition is that such patients suffer from Rh null syndrome associated with osmotically fragile red cells called stomatocytes (the picture) with subsequent chronic hemolytic anemia of varying degree. Another importance is that such subjects readily form alloantibodies on exposure to Rh antigens.
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